Abstracts

2012

Lugea A; Javaherizadeh P, Hui H; Waldron RT; Pandol SJ. Rottlerin promotes apoptosis and autophagy in pancreatic stellate cells via AMPK activation. DDW Abstract, 2012.

Lu, Q.Y., Zhang, L., Moro, A., Chen, M., Harris, D.M., Eibl, G., and V.L.W. Go. 2011. Bioavailability of bioactive compounds of Scutellaria baicalensis in mouse pancreas and pancreatic xenografts. 52nd Annual Meeting of the American Society for Pharmacognosy. San Diego, CA, July 30-August 3.

Takahashi, H., Chen, M.C., Harris, D.M., Reber, H.A., Hines, O.J., Go, V.L.W. and G. Eibl. 2011. Baicalein induces apoptosis in pancreatic cancer cells by down-regulation of MCL-1. 52nd Annual Meeting of the American Society for Pharmacognosy. San Diego, CA, July 30-August 3.

Takahashi, H., Brovman, E.Y., Matsuo, Y.,Ishiguro, H.,Chen, M.C., Pham, H., Reber, H.A., Takeyama, H., Hines, O.J., and G. Eibl. 2012.Knock-down of Bcl-xL and Mcl-1 synergistically induces apoptosis in gemcitabine-sensitive and -resistant pancreatic cancer cells. Academic Surgical Congress. Las Vegas, NV, February 14-16.

Pham,H., Chen, M.C., King, J.,Takahashi, H., Park, J., Pandol^,S., Reber, H.A. Hines, O.J., and G. Eibl. 2012. Apigenin inhibits NNK-induced FAK Y397 activation in pancreatic cells. American Association for Cancer Research Meeting, Chicago, IL, March 31-April 4.

Chen, M.C., Esquivel, S., Reber, H.A., Hines, O.J., Go, V.L.W. and G. Eibl. 2011. Eicosapentaenoic Acid Down-regulates Fatty Acid Synthase Expression through an Akt-dependent Pathway in Pancreatic Cancer Cells. Proceedings of the 42nd Annual Meeting of the American Pancreatic Association. Chicago, IL, November 2-5.

R.A. Hicks, B.F. Ferreira, C.S. Mao, J.K. Yee, and W.N.P. Lee The use of 17-α-hydroxyprogesterone to 11-deoxycortisol ratio in newborn screening of congenital adrenal hyperplasia. Presented at WSPR Meeting, Carmel, February 2012.

Jennifer K. Yee, Ashley Martin, Shu Lim, Juan Vega, Joshua Cohen, Paulin Wahjudi, Wai-Nang Paul Lee Effects on Fructose on Glucose Utilization for Fatty Acid Synthesis in 3T3-L1 Adipocytes. Presented at WSPR Meeting, Carmel, February 2012.

Yasmeen Rahimi, Nam Ho Jeoung, Pengfei Wu, Martha S. Kuntz, W.N. Paul Lee, and Robert A. Harris. Importance of pyruvate dehydrogenase kinases in the regulation of blood levels of glucose and the metabolism of ketone bodies and fatty acids Submitted for the Annual Meeting of the Diabetes Association, Philadelphia, June 2012.

Hicks, Rebecca; Lee, Paul; Yee, Jennifer and Mao, Catherine. Profiling Precursor-Product Ratio In Newborn Screening Of Congenital Adrenal Hyperplasia. Presented at the Annumal Meeting of the Metabolomics Society, Washington DC, June 2012

H.Takahashi, E.Y.Brovman, Y.Matsuo, H.Ishiguro, M.Chen, H.Pham, H.A.Reber, H.Takeyama, G.Eibl, O.J.Hines. Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis in gemcitabine-sensitive and –resistant pancreatic cancer cells. J Surg Res 2012;172(2):222-223

G.W.Donald, M.Assifi, A.Moro, M.Chen, G.Eibl, H.A.Reber, D.Dawson, V.G.Li, O.J. Hines. Enhanced Growth of Syngeneic Pancreatic Cancer in CXCR2 Deficient Mice. J Surg Res 2012;172(2):309-310

H.Pham, M.Chen, H.Takahashi, H.A.Reber, O.J.Hines, G.Eibl. Vitamin D3 induces 15-hydroxyprostaglandin dehydrogenase to suppress pancreatic cancer cell proliferation [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR; 2012. Abstract nr 62

A.Lugea, A.Moro, R.T.Waldron, G.Eibl, S.J.Pandol. Reciprocal enhancement of PaSC activation and PanIN lesion development: effects of high fat diets and ethanol. Gastroenterology 2012

K.Kisfalvi, J.Sinnett-Smith, S.H.Young, G.Eibl, E.Rozengurt. Berberine inhibits the growth of human pancreatic cancer cells in vitro and in vivo. Gastroenterology 2012

2011

Yee, Jennifer K.; Wahjudi, Paulin N..; Patterson, Mary E.; Lim, S.;Mao, C.;Lee, W. Monounsaturated Fatty Acids Incompletely Rescue 3T3-L1 Cells from Effects of SCD1 Inhibition, Journal of Investigative Medicine, 2011,59,190

E.Y. Brovman, H. Takahashi, M. Chen, V.L.W. Go, H.A. Reber, G. Eibl, and O.J. Hines. Baicalein Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine through Modulation of Mcl-1 Expression. J Surg Res 2011;165(2):177

H. Takahashi, M.C. Chen, D.M. Harris, H.A. Reber, O.J. Hines, V.L.W. Go, and G. Eibl. Baicalein Induces Apoptosis in Pancreatic Cancer Cells by Down-Regulation of MCL-1. . 52nd annual meeting of the American Society for Pharmacognosy, 2011.

H.Takahashi, M.C.Chen, D.M.Harris, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Baicelein induces apoptosis in pancreatic cancer cells by down-regulation of Mcl-1. 52nd Annual meeting of the American Society of Pharmacognosy, San Diego, CA, USA, July 30 – August 2, 2011

J.C.King, A.Li, H.A.Reber, G.Eibl, O.Hines. CXCL5-mediated signaling events and in vitro angiogenesis in human pancreatic cancer. J Surg Res 2011;165(2):226

M. Edderkaoui, A. Lugea, A. Moro, G. Eibl, H. Hui, G. Li, V.L.W. Go, A. Gukovskaya, and S. Pandol. Ellagic Acid and Embelin: Potential Pancreatic Cancer Preventive and Treatment Agents. 101st Annual Meeting of the American Association for Cancer Research, 2011.

M.Edderkaoui, A.Lugea, A.Moro, G.Eibl, H.Hui, G.Li, V.L.Go, A.Gukovskaya, S.Pandol. Ellagic acid and embelin: potential pancreatic cancer preventive and treatment agents [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Florida. Philadelphia (PA): AACR; 2011. Abstract 4595

M.M.Assifi, X.Lu, G.Eibl, H.A.Reber, G.Li, O.J.Hines. Neoadjuvant therapy in pancreatic adenocarcinoma; a meta-analysis of phase II trials. J Surg Res 2011;165(2):305

Patterson, Mary E.; Wahjudi, Paulin N.; Mao, Catherine; Yee Jennifer K.; Lee, PW. Synergistic Effect of Fructose and Insulin on Glucose Metabolism in HepG2 Cells, Journal of Investigative Medicine, 2011, 59, 120

Patterson, Mary E; Wahjudi, Paulin N.; Yee Jennifer K.; Lee, PW. A Bioassay of Insulin Bioactivity Using HepG2 Cells in Culture, Journal of Investigative Medicine, 2011, 59,192

Q.Y. Lu, L. Zhang, A. Moro, M.C. Chen, D.M. Harris, G. Eibl, and V.L.W. Go. Bioavailability of Bioactive Compounds of Scutellaria Baicalensis in Mouse Pancreas and Pancreatic Xenografts. 52nd annual meeting of the American Society for Pharmacognosy, 2011.

Wahjudi, Paulin N.; Patterson, Mary E.; Lu, Qing-Yi; Chen, Jian; Li, Wei-Lin; Lee, WNP. In-vitro Tracer-Based Investigation on the Effect of Loquat Leaves Extract Toward Glucose Metabolism using HepG2 cells. Experimental Biology 2011, Washington DC, April 9-13, 2010.

Chudasama Y, Lugea A, Lu QY, Pandol SJ. Beta Cyclodextrin increases bioavailability of Ellagic acid in rats. DDW Abstract, 2011.

K.Kisfalvi, J.Sinnett-Smith, G.Eibl, E.Rozengurt. Metformin inhibits the growth of human pancreatic cancer cells implanted in nu/nu mice. Gastroenterology 2011;140(5):S-682

H.Takahashi, M.C.Chen, D.M.Harris, H.Pham, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Anti-apoptotic Bcl-2 family protein Mcl-1 plays a critical role in baicalein-induced apoptosis in human pancreatic cancer cells. Gastroenterology 2011;140(5):S-684

H.Pham, M.C.Chen, H.Takahashi, H.A.Reber, O.J.Hines, G.Eibl. Vitamin D3 regulates 15-hydroxyprostaglandin dehydrogenase in human pancreatic cancer cells. Gastroenterology 2011;140(5):S-861

M.C.Chen, J.L.Park, P.Srihari, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Eicosapentaenoic Acid Induces Apoptosis through an Akt-dependent pathway in Pancreatic Cancer Cells. Pancreas 2011;40(8):1316

M.C.Chen, S.Esquivel, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Eicosapentaenoic Acid Decreases Fatty Acid Synthase Through an Akt-Dependent Pathway in Pancreatic Cancer Cells. Pancreas 2011;40(8):1316

C.J.Nitsche, R. Moore, C.D.Heidecke, M.Edderkaoui, G.Eibl, N.Kasahara, J.Mayerle, M.M.Lerch, A.S.Gukovskaya. Tumor-Suppressor Role of PHLPP1 in Pancreatic Ductal Adenocarcinoma is Mediated Through Inhibiting of Akt2. Pancreas 2011;40(8):1344

M.Satake, G.Eibl, N.Kuroda, T.Hirano, H.Ishikawa, M.Nishii, A.Babaya, V.L.Go, H.Reber, Y.Fukuda, O.J.Hines, J.Fujimoto. COX-2 Depending CXC-chemokines Production in Human Pancreatic Cancer Cells. Pancreas 2011;40(8):1352

K.Kisfalvi, J.Sinnett-Smith, G.Eibl, E.Rozengurt. Metformin inhibits the growth of human pancreatic cancer cells implanted in nu/nu mice. Gastroenterology 2011;140(5):S-682

H.Pham, M.C.Chen, H.Takahashi, H.A.Reber, O.J.Hines, G.Eibl. Vitamin D3 regulates 15-hydroxyprostaglandin dehydrogenase in human pancreatic cancer cells. Gastroenterology 2011;140(5):S-861

M.C.Chen, J.L.Park, P.Srihari, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Eicosapentaenoic Acid Induces Apoptosis through an Akt-dependent pathway in Pancreatic Cancer Cells. Pancreas 2011;40(8):1316

M.C.Chen, S.Esquivel, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Eicosapentaenoic Acid Decreases Fatty Acid Synthase Through an Akt-Dependent Pathway in Pancreatic Cancer Cells. Pancreas 2011;40(8):1316

2010

Yee JK, Han G, Lee WN, Ross MG, Desai M. Rosiglitazone Treatment Increases Glucose Utilization and Fatty Acid Synthesis In Adipocyte Cultures From IUGR Newborns. Presented at the Pediatric Academic Societies (PAS) Meeting, Vancouver, Canada, May 2010.

E. Angst, J. Park, A. Moro, Q.-Y. Li, J.C. King, V.L.W. Go, H.A. Reber, G. Eibl, O.J. Hines. Quercetin inhibits growth of pancreatic ccancer in vitro and in vivo. In: Proceedings of the 101th Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia PA: AACR; 2010. Abstract 4179

H. Takahashi, M.C. Chen, D.M. Harris, H. Pham, H.A. Reber, O.J. Hines, V.L.W. Go, and G. Eibl. Down-regulation of Mcl-1 by Baicalein Induces Apoptosis through the Mitochondrial Pathway in Human Pancreatic Cancer Cells. Proceedings of the 41st annual meeting of the American Pancreatic Association, 2010.

H.Takahashi, M.C.Chen, D.M.Harris, H.Pham, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Down-regulation of Mcl-1 by baicalein induces apoptosis through the mitochondrial pathway in human pancreatic cancer cells. Pancreas 2010;39(8):1350

J.C. King, Q.-Y. Lu, L. Zhang, G. Li, A. Moro, H.A. Reber, V.L.W. Go, G. Eibl, and O.J. Hines. Apigenin Induces Pancreatic Cancer Apoptosis Via p53 and PUMA. Pancreas 2010;39(8):1327

J.C.King, Q.-Y.Lu, L.Zhang, G.Li, A.Moro, H.A.Reber, V.L.W.Go, G.Eibl, O.J.Hines. Apigenin induces pancreatic cancer apoptosis via p53 and PUMA. Pancreas 2010;39(8):1327

JK Yee, G Han, WN P Lee, MG Ross, M Desai. In Vivo and Ex Vivo Models of Enhanced Adipocyte Differentiation in Intrauterine Growth Restricted Neonatal Rats. Presented at the WSPR Meeting, Carmel CA, February 2010.

K.Kisfalvi, J.Sinneth-Smith, G.Eibl, E.Rozengurt. Targeting the synergistic crosstalk between insulin and G protein-coupled receptor signaling by metformin potently inhibits pancreatic cancer cell proliferation in vitro and in vivo. Pancreas 2010;39(8):1328

Lee WN, Xu J, Wahjudi PN and Go VL. Application of Tracer-based Metabolomics and Phenotypic Phase Plane Analysis in Metabolic Studies. Submitted for presentation at the Annual Meeting of the Metabolomics Society, Amsterdam, Holland, June 2010.

Lee WN, Xu J, Wahjudi PN and Go VL. Application of Tracer-based Metabolomics in Quantitative and System Pharmacology. NIGMS Quantitative and Systems Pharmacology Workshop II, Bethesda, September 2010.

M. Edderkaoui, H. Hui, G. Li, J. Xu, W.N.P. Lee, V.L.W. Go, and S. Pandol. Phytochemicals Inhibit Proliferation and Promote Death through NADPH Oxidose and G6PHD. Annual meeting of The American Association of Cancer Research, 2010.

M. Satake, N. Kuroda, N. Uyama, T. Hirano, T. Okada, G. Eibl, V.L.W. Go, O.J. Hines, H. Reber, and J. Fujimoto. A Selective COX-2 Inhibitor Inhibits CXC Chemokine Production in Human Pancreatic Cancer Cells. Pancreas 2010;39(8):1345

M.C. Chen, H. Takahashi, J.L. Park, H. Pham, H.A. Reber, O.J. Hines, V.L.W. Go, and G. Eibl. Eicosapentaenoic Acid Induces Apoptosis in Pancreatic Cancer Cells. Pancreas 2010;39(8):1314

M.Satake, N.Kuroda, N.Uyama, T.Hirano, T.Okada, G.Eibl, V.L.W.Go, O.J.Hines, H.Reber, J.Fujimoto. A selective COX-2 inhibitor inhibits CXC chemokine production in human pancreatic cancer cells. Pancreas 2010;39(8):1345

P.N. Wahjudi, E. Hsieh, M.E. Patterson, C.S. Mao, W.P. Lee. Carbohydrate analysis of high fructose corn syrup containing commercial beverages. Presented at EB2010, Anaheim, CA. April 2010.

P.N. Wahjudi, G.G. Xiao, W.P. Lee, M.W. Nowak, N. Shiva. Determination of protein synthesis in vivo with 15N-glycine labeling and MALDI-TOF spectrum analysis. Presented at EB2010 Meeting, Anaheim, CA. April 2010.

Patterson, ME, Wahjudi, PN and Lee WNP. Acute Metabolic and Hormonal Responses to HFCS Ingestion in Obese and Diabetic Adolescents. Presented at the Pediatric Academic Societies (PAS) Meeting, Vancouver, Canada, May 2010.

2009

Rui Cao; Hengwei Zhang; W. Paul Lee; Caishu Deng; Yingchun Zhao; Qingmei Xie; Joan Lappe; Robert Recker; Songping Liang, Gary Guishan Xiao. Oxythiamine specifically inhibits heat shock protein 27 (Hsp27) phosphorylation and cell proliferation in MIA pancreatic cancer cells. Presented at 57th ASMS Conference on Mass Spectrometry and Allied Topics in Philadelphia, May 2009.

Wahjudi PN, Patterson ME, Lim S, Yee J, Mao CS, Lee W. “Postprandial serum fructose level in patients tested for diabetes.” Presented at the WSPR Meeting, Carmel, CA, January 30, 2009.

Yee JK, Patterson M, Lim S, Mao C, Lee WP. “Inhibition of early differentiation of NIH3T3 preadipocytes by stearoyl-CoA desaturase inhibitors.” Presented at the WSPR Meeting, Carmel, CA, January 30, 2009.

Z.Yingchun, J.Xiao, W.N.Lee, R.Cao, R.Recker, V.L.W.Go, G.G.Xiao. Secretome profiling in pancreatic cancer cells in response to transketolase inhibitor oxythiamine using 15N amino acid labeling and serum-depleted medium. Presented at 57th ASMS Conference on Mass Spectrometry and Allied Topics in Philadelphia, May 2009.

A. Li, J. King, A. Moro, M.D. Sugi, D.W. Dawson, J. Kaplan, G. Li, X. Lu, V.L.W. Go, H.A. Reber, G. Eibl, O. Joe Hines. CXCL5 Correlates with Survival and Mediatates Pancreatic Cancer Growth. Pancreas 2009;38(8):1023

A.Li, J.C.King, M.D.Sugi, R.M.Strieter, M.D.Burdick, H.A.Reber, G.Eibl, O.J.Hines. CXCL5[ENA-78] is overexpressed in pancreatic cancer and mediated pancreatic cancer-derived angiogenesis. Gastroenterology 2009;136(5):A312

A.Li, J.Park, S.Kang, H.A.Reber, O.J.Hines, G.Eibl. Pronounced effects of n-3 and n-6 polyunsaturated fatty acids in pancreatic cancer cells using three-dimensional growth assays. Gastroenterology 2009;136(5):A315

C.J.Nitsche, M.Edderkaoui, V.L.W.Go, M.M.Lerch, A.S.Gukovskaya. Phosphatases PHLPP 1 and PHLPP2 dephosphorylate Akt through NADPH-oxidase-dependent mechanism leading to pancreatic cancer cell death. AACR Meeting Abstracts, 2009. 2009(1_Annual_Meeting)

E. Angst, J. Park, A. Moro, P.W.N. Lee, V.L.W. Go, H.A. Reber, G. Eibl, O.J. Hines. Quercetin Enhances Apoptosis and Inhibits Angiogenesis in Pancreatic Cancer Cells. Pancreas 2009;38(8):981

E.Angst, D.W.Dawson, A.Nguyen, J.Park, H.A.Reber, O.J.Hines, G.Eibl. Epigenetic regulation affects N-myc downstream regulated gene-1 expression in pancreatic cancer cells [abstract]. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract 4246

E.Angst, J.Park, V.L.Go, H.A.Reber, G.Eibl, O.J.Hines. Growth inhibitory effects of quercetin in pancreatic cancer cells. Alternative Therapies 2009;15(3):S80

E.Angst, M.Kim, J.Park, B.Gloor, H.A.Reber, O.J.Hines, G.Eibl. N-myc downstream regulated gene-1 correlates with reduced pancreatic cancer growth in vitro and in vivo. Gastroenterology 2009;136(5):A33

Edderkaoui, M.; Nitsche, C. J.; Eibl, G.; Gukovskaya, A. S., Akt and PKC mediate NADPH oxidase activation, a major prosurvival pathway in pancreatic cancer cells, through transcriptional up-regulation of p22phox. AACR Meeting Abstracts, 2009.

H. Hui, Y.G. Tang, K.Y. Wang, S.J. Pandol, V.L.W. Go. Inhibitory Effects of GLP-1 on Proliferation and Tumiorgenicisty of Pancreatic Cancer Stem Cells In Vitro .Pancreas 2009;38(8):1005

H. Hui, Y.G. Tang, L. Zhu, N. Khoury, K.Y. Wang, R. Perfetti, S.J. Pandol, V.L.W. Go. GLP-1 Directed Human Embryonic Stem Cells Differentiation Into Insulin Producing Cells Via Hedgehog, CAMP, PI3K Pathways. Pancreas 2009;38(8):1005

H.Pham, A.Li, M.Chen, J.King, E.Angst, D.Dawson, O.J.Hines, G.Eibl. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors[abstract]. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract 4361

H. Takahashi, M.C. Chen, D.M. Harris, H.A. Reber, O.J. Hines, G. Eibl, V.L.W. Go. Baicalein, a Component of Scutellaria Baicalensis (SB), Inhibits Nuclear Factor-JB Activity and Induces Apoptosis in Human Pancreatic Cancer Cells. Pancreas 2009;38(8):1053

Hengwei Zhang; Rui Cao; W. Paul Lee; Caishu Deng; Yingchun Zhao; Jing Xiao; Qingmei Xie; Shu Lim; Vay Liang Go; Robert Recker; Gary Guishan Xiao. Differential Expression Of Cellular Proteins In Pancreatic Cancer Cells In Response To Transketolase Inhibitor Oxythiamine Treatment. Presented at 57th ASMS Conference on Mass Spectrometry and Allied Topics in Philadelphia, May 2009.

J.C.King, A.Li, M.Sugi, D.Dawson, G.Eibl, H.A.Reber, O.J.Hines. CXCL5 expression heralds a worse prognosis for pancreatic cancer patients. 95th Annual Clinical Congress, American College of Surgeons, Chicago, IL, October 11-15, 2009

J.King, H.A.Reber, G.Eibl, A.Li, O.J.Hines. A comparison of laparoscopic and open distal pancreatectomy. Gastroenterology 2009;136(5):A931

K.Gao, H.Zhou, L.Zhang, J.W.Lee, Q.Zhou, S.Hu, J.Farrell, G.Eibl, D.Wong. Induction of systemic disease-specific salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer [abstract]. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract 314

K.Kisfalvi, J.Sinneth-Smith, G.Eibl, E.Rozengurt. Metformin inhibits the growth of human pancreatic cancer cells in vitro and in vivo. Gastroenterology 2009;136(5):A312

M. Edderkaoui, H. Hui, J. Markus, G. Li, V.L.W. Go, A.S. Gukovskaya, S.J. Pandol. Synergistic Effects of Embelin and Ellagic Acid on Pancreatic Cancer. Pancreas 2009;38(8):994

M. Satake, N. Kuroda, N. Uyama, T. Hirano, T. Okada, G. Eibl, V.L.W. Go, O.J. Hines, H. Reber, K. Suzumura, J. Fujimoto. The Comparative Study of Angiogenetic and Angiostatic CXC Chemokines in Human Pancreatic Cancer. Pancreas 2009;38(8):1043

M. Satake, N. Kuroda, N. Uyama, T. Hirano, T. Okada, M. Takahashi, G. Eibl, V.L.W. Go, J. Fujimoto. COX-2 Expression and Opposite Growth Effect of N-3 and-6 PUFAs in Pancreatic Cancer Cell Lines. Pancreas 2009;38(8):1043

M.C. Chen, V.L.W. Go, G. Eibl, S.V. Wu. Identification and Functional Characterization of Corticotropin Releasing Hormone (CRH) Receptors in Human Pancreatic Cancer Cells. Pancreas 2009;38(8):988

M.C.Chen, D.M.Harris, Q.Y.Lu, E.Angst, J.Park, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Growth inhibitory effects of polyphenols in Scutellaris baicalensis in pancreatic cancer cells. Digestive Disease Week 2009.

M.Edderkaoui, C.J.Nitsche, G.Eibl, A.S.Gukovskaya. Akt and PKC mediate NADPH oxidase activation, a major prosurvival pathway in pancreatic cancer cells, through transcriptional up-regulation of p22phox [abstract]. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract 4396

Mouad Edderkaoui, Ling Zheng, Hongxiang Hui, Gang Li, Vay Liang W. Go, Stephen Pandol. Mechanisms underlying the beneficial synergistic effects of phytochemicals on pancreatic cancer. DDW 2009. Gastroenterology. Vol 136 Suppl2; 2009.

M.Satake, K.Nobukazu, U.Naoki, H.Tadamichi, G.Eibl, A.Yasukane, V.L.W.Go, J.Fujimoto. COX-2 expression and opposite growth effects of n-3 and n-6 PUFAs in three novel pancreatic Adenocarcinoma cell lines. Gastroenterology 2009;136(5):A278

M.C.Chen, D.M.Harris, Q.Y.Lu, E.Angst, J.Park, H.A.Reber, O.J.Hines, V.L.W.Go, G.Eibl. Growth inhibitory effects of polyphenols in Scutellaria baicalensis in pancreatic cancer cells. Gastroenterology 2009;136(5):A313

Nitsche, C. J.; Edderkaoui, M.; Go,Vay Liang W. (Bill) Lerch, M. M.; Gukovskaya, A. S., Phosphatases PHLPP 1 and PHLPP 2 dephosphorylate Akt through NADPH-oxidase-dependent mechanism leading to pancreatic cancer cell death. AACR Meeting Abstracts, 2009.

2008

A.Li, E.Angst, R.M.Strieter, M.Sugi, H.A.Reber, G.Eibl, O.J.Hines. CXCL5[ENA-78] mediates pancreatic cancer derived angiogenesis. Pancreas 2008;37(4):479-480

A.Li, E.Angst, S.Hasan, D.D.Dawson, J.Park, H.A.Reber, O.J.Hines, G.Eibl. COX-2 expression confers growth advantage to isogeneic pancreatic cancer cells in vitro and in vivo. AACR Conference Proceedings “Chemical and Biological Aspects of Inflammation and Cancer”

A.Li, S.Hasan, E.Angst, H.A.Reber, O.J.Hines, G.Eibl. Expression of COX-2 confers growth advantage to pancreatic cancer cells. DDW 2008

A.Li, S.Hasan, E.Angst, J.Park, H.A.Reber, O.J.Hines, G.Eibl. Growth advantage of COX-2 expressing pancreatic cancer cells in vitro and in vivo. Pancreas 2008;37(4):480

E.Angst, J.Park, V.L.Go, H.A.Reber, G.Eibl, O.J.Hines. Growth inhibitory effects of quercetin in pancreatic cancer cells. Pancreas 2008;37(4):459

E.Angst, J.Park, V.L.W.Go, H.A.Reber, G.Eibl, O.J.Hines. Growth inhibitory effects of quercetin in pancreatic cancer cells. North American Research Conference on Complementary & Integrative Medicine

E.Angst, S.Hasan, B.Gloor, H.A.Reber, O.J.Hines, G. Eibl. N-myc downregulated gene-1 reduces cell growth via enhanced apoptosis. Pancreas 2008;37(4):459-460

E.Angst, S.Hasan, M.Kim, A.Li, B.Gloor, H.A.Reber, O.J.Hines, G.Eibl. Expression of N-myc Downregulated Gene-1 Attenuates Pancreatic Cancer Cell Growth [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract 1943

H.Funahashi, E.Angst, M.Satake, S.Hasan, H.A.Reber, O.J.Hines, G.Eibl. The omega-3 polyunsaturated fattyacid EPA decreases the growth of pancreatic cancer cells by COX-2 dependent and independent mechanisms. J Surg Res 2008;144(2):311

Lee WNP, Lim S, Wahjudi P, Go VL and Xiao GG. Compartmentalization of Amino Acid Synthesis in HepG2 cells: Insight from Isotopomer analysis. Abstract submitted to the Annual Meeting of the Metabolomics Society, Boston, 2008.

M. Garg, M. Thamotharan, W.N. Paul Lee and S.U. Devaskar. Early Postnatal Caloric Restriction Reverses Obesity and Glucose Intolerance in the Aging Intra-Uterine Growth Restricted Male Offspring. Presented at Pediatric Academic Societies Meeting Honolulu, Hawaii, May 2008.

M.Edderkaoui, C.J.Nitsche, G.Eibl, A.S.Gukovskaya. Role of different subunits of NADPH oxidase in IGF-I-induced ROS production and pro-survival effect in pancreatic cancer cells [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract 4374

M.Edderkaoui, C.J.Nitsche, G.Eibl, A.S.Gukovskaya. Role of different subunits of NADPH oxidase in IGF-I-induced ROS production and pro-survival effect in pancreatic cancer cells. DDW 2008

M.Satake, T.Hamada, G.Eibl, K.Suzumura, T.Hirano, T.Okada, N.Kuroda, V.L.Go, J.Fujimoto, T. Tsujimura. Pancreas-transdifferentiation induced by signal transduction system of stem cell factor and c-kit receptor tyrosine kinase. Pancreas 2008;37(4):

M.Satake, T.Hamada, G.Eibl, K.Suzumura, T.Hirano, T.Okada, N.Kuroda, V.L.Go, J.Fujimoto, T. Tsujimura. Pancreatic transdifferentiation induced by signal transduction system of c-kit receptor tyrosine kinase and its ligand stem cell factor. DDW 2008

Meena Garg, M. Thamotharan, Paul WN Lee, and Sherin U. Devaskar. Early Intervention with a Peroxisome Proliferator-Activated Receptor (PPAR) Agonist Improves Insulin Sensitivity in the Pre-Gestational Adult IUGR Offspring. Presented at Pediatric Academic Societies Meeting Honolulu, Hawaii, May 2008.

S.Hasan, M.Satake, D.D.Dawson, H.Funahashi, E.Angst, V.L.W.Go, H.A.Reber, O.J.Hines, G.Eibl. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas 2008;37(2):121-127

Xiao G, Ferreri K, Scott S, Lim S, Go VL, Lee WNP. Glucose Utilization by Alpha and Beta Cells of Isolated Islets from Rats: A Proteomics Study. Submitted to American Diabetes Association Annual Meeting, 2008.

Xiao J, Lee WNP, Lim S, Zhao Y, Recker RR, Xiao GG. Biomarker discovery using low enrichment of stable isotope. . Submitted to Annual Meeting of ASMA, 2008.

Yee JK , Lim S, Mao CS, Lee WNP. Inhibition Of Stearoyl-CoA Desaturase Enzyme Decreases Adipocyte Differentiation In NIH3T3 Preadipocytes. Submitted to American Diabetes Association Annual Meeting, 2008.

Yee JK, Lim S, Desai M, Ross M, Lee WNP. Role of Stearoyl-CoA Desaturase in Prenatal Nutritional Programming of Adult Obesity in Rats. Presented at the WSPR meeting, February 2008.

Zhao Y, Lee WNP, Lim S, Xiao J, Recker RR, Xiao GG. Measuring Protein Synthesis as Part of Proteomics Study on Pancreas Cancer Cell Proliferation. Submitted to Annual Meeting of ASMS 2008.

2007

H.Funahashi, M.Satake, S.Hasan, E.Angst, H.A.Reber, O.J.Hines, G.Eibl. The n-3 polyunsaturated fatty acid EPA inhibits pancreatic cancer cell growth by COX-2 dependent and independent mechanisms. Pancreas 2007;35(4):403